In a career spanning two decades, he has appeared in multiple film and television projects spanning a variety of genres. He is a five-time Teen Choice Award nominee.

His most notable roles include Hannah Montana: The Movie (2009), The Spy Next Door (2010), and Monster Trucks (2016). Till portrayed Havok in the X-Men prequel films from 2011 to 2016, and starred in the 2016 CBS reboot of the 1985 television series MacGyver as the titular character until its end in 2021. In 2020, he starred as Bob Zellner in the biographical drama Son of the South, to critical acclaim.