In 2007, she and her family began starring in the reality television series Keeping Up with the Kardashians. Its success led to the creation of spin-offs including Kourtney and Khloé Take Miami and Kourtney and Kim Take New York.

With sisters Kim and Khloé, Kardashian is involved in the retail and fashion industries. They have launched several clothing collections and fragrances, and additionally released the book Kardashian Konfidential in 2010. Kourtney launched her own website called Poosh in early 2019.